Cretinism thyroid

Cretinism is a congenital disorder meaning it is present at birth. In this disorder, there is reduced or absent thyroid function as well as the production of thyroid hormone. If this condition is not treated in time, it may result in severe stunted mental and physical growth of a baby Subsequent investigation confirmed the presence of a lingual thyroid. Features of cretinism were present despite the late presentation. This unusual case is discussed with reference to previous publications A recent report highlights a decrease in wound healing in mice which emphasizes the overall important activity of thyroid hormones in the skin. cretinism is the condition of stunted physical and mental development due to the lack of treatment of congenital hypothyroidism. The most common etiology is due to maternal hypothyroidism Also called cretinism Congenital hypothyroidism (CH) is a clinical condition characterized by absence of thyroid hormone secondary to abnormal thyroid gland developmental or biosynthesis disorders (J Coll Physicians Surg Pak 2013;23:214) This topic also contains links to its two causes, Aplasia / hypoplasia and Dyshormonogenetic goite Congenital hypothyroidism, previously known as cretinism, is a severe deficiency of thyroid hormone in newborns. It causes impaired neurological function, stunted growth, and physical deformities...

Cretinism is a condition arising from the deficiency of thyroid hormone, which causes dwarfism and mental retardation. It is present from birth. Congenital hypothyroidism is considered to be common, genetic or periodic. If left untreated, it can result into mild to severe impairment of physical and mental growth and development Congenital hypothyroidism (CH) is thyroid hormone deficiency present at birth. If untreated for several months after birth, severe congenital hypothyroidism can lead to growth failure and permanent intellectual disability Clinical presentation. Most children are asymptomatic at birth and are diagnosed after screening. In untreated congenital hypothyroidism, patients can present with short stature, disproportionately enlarged heads and/or developmental delay / intellectual disability 5.. Patholog

Cretinism - Definition, Causes, Diagnosis, Treatment

Among the other celebrities who survived thyroid cancer: Actress Catherine Bell (JAG) is a thyroid cancer survivor and also a spokesperson for the Thyroid Cancer Survivors' Association. Comedian and actor Joe Piscopo is a long-term thyroid cancer survivor. His thyroid cancer was diagnosed in the 1990s Cretinism refers to the congenital hypothyroidism or underactivity of thyroid glands during early childhood leading to stunted growth and mental retardation. The term cretin was derived from the French word chrétien, literally meaning Christian or Christ-like as the diseased were mentally retarded and incapable of doing sin Neurological Cretinism It is caused by thyroid deficiency in moths during the first and second trimesters of pregnancy. This leads to fetal iodine deficiency and consequent thyroid insufficiency, leading to neurological problems like inability to hear and perform motor functions and brain damage

Cretinism and lingual thyroid presenting in an adult

Neurologic cretins may not be hypothyroid (lack of thyroid hormones) later in life if they receive sufficient iodine that makes the thyroid produce sufficient thyroid hormones. However damage done during development of brain is irreversible Cretinism is a condition of severe physical and mental retardation due to iodine deficiency, and specifically due to deficiency of thyroid hormones during early pregnancy

Hypothyroidism (cretinism) - Dermatology Adviso

  1. Cretinism is a medical condition present at birth wherein there is a decreased or absent thyroid function and thyroid hormone production. When untreated, this could lead to severely stunted physical and mental growth of the newborn. This is also known as Congenital Hypothyroidism. Picture 1: A Child with Cretinism
  2. The word cretin is termed as the iodine deficiency disorder which is associated with insufficient intake of the thyroid hormone activity that occurs during the fetal, infant or childhood phases
  3. Cretinism refers to severe hypothyroidism in an infant or child. This is classically the result of maternal iodine deficiency, and thankfully is increasingly rare. Thyroid. 2012 Dec. 22(12.
  4. ♻ THYROID & PARATHYROID GLANDS ♻ *THYROID GLAND BUTTERFLY SHAPED GLAND* *Dear Student in this video lecture we will study following important topics from..
  5. cretinism A condition caused by thyroid underaction from severe iodine deficiency early in life. It features dwarfism, mental retardation, dry skin, a large tongue and a puffy face. Cretinism occurs mainly in regions remote from the sea
  6. Thyroid destruction leading to endemic myxoedematous cretinism is highly prevalent in central Africa, where iodine (I) and selenium (SE) deficiencies as well as thiocyanate (SCN) overload are combined. All three factors have been studied experimentally in the etiology of the disease, but they have n

Pathology Outlines - Congenital hypothyroidis

  1. HOPE YOU LIKE THIS VIDEO#pathology #anatomy #thyroid_gland #endocrine_gland_disorders #thyroid_gland_disorder #hypothyroidsm #cretinism
  2. Cretinism is an irreversible brain damage, irreversible mental retardation and severely stunted physical growth in an infant or child due to severe iodine deficiency during pregnancy caused by inadequate thyroid hormone production (congenital hypothyroidism) 1)
  3. Cretinism. Thyroid hormone metabolism. Molecular and Cellular Endocrinology, 81 (1991) C193-C195 1991 Elsevier Scientific Publishers Ireland, Ltd. 0303-7207/91 /$03.50 C193 MOLCEL 02638 At the Cutting Edge Cretinism, thyroid hormones and selenium B. Contempre, J. Vanderpas and J.E. Dumont I.R.I.B.H.N., Unwersite Libre de Bmxelles, B-1070.
  4. cretinism was essentially a neurological dis-order, a conclusion that was based on find-ings of normal thyroid function, radiologi-cal abnormalities of the skull and disturbed electroencephalograms. In contrast, Stanbury and coworkers 10 proposed that endemic cre-tinism was caused by a functional thyroid hormone deficiency, occurring during em

thyroid hormone deficiency present at birth. cretinism refers to the state of developmental delay secondary to untreated congenital hypothyroidism. Epidemiology. demographics. most common neonatal endocrine disorder. 2:1 female-to-male ratio. risk factors. gestational age > 40 weeks. Pathogenesis Thyroid Hypofunction - Congenital Hypothyroidism (Cretinism) Hypothyroidism is one of the most common endocrine problems of childhood. It may be either congenital, such as in cretinism, or acquired, such as from autoimmunization (Hasimotos's thyroditis). Hypothyroidism from dietary insufficiency of iodine is now rare because the use of iodized. Cretinism can lead to severe developmental and physical delays, as well as abnormal physical features. The New York Times reports that untreated congenital hypothyroidism can often cause irreversible damage since thyroid hormones are vital for nervous system development soon after birth

Newborn screening for congenital hypothyroidism (first published in 1973), obtained by heel stick, has almost eliminated the profound negative effects of thyroid hormone deficiency in growth and development (cretinism) in the countries where it is available In the most severe form, an underactive thyroid can result in cretinism (a syndrome characterized by permanent brain damage, deaf mutism, spasticity, and short stature), although this has become rare worldwide. Iodine deficiency is the most common preventable cause of intellectual disabilities in the world The thyroid radiation dose depends on the RAIU as well as the biological and effective half-life of the radioiodine in the thyroid gland. This biological half-life can vary widely. Thyroid concentrations toward the upper end of the range (i.e., 7.4 MBq/gm [200 μCi/gm]) are especially suitable for patients with nodular goiters, very large toxic. Among the other celebrities who survived thyroid cancer: Actress Catherine Bell (JAG) is a thyroid cancer survivor and also a spokesperson for the Thyroid Cancer Survivors' Association. Comedian and actor Joe Piscopo is a long-term thyroid cancer survivor. His thyroid cancer was diagnosed in the 1990s Neurological Cretinism It affects the nervous syste and caused by lack of thyroid hormones from the mother during third to sixth month of pregnancy, the severe lack of iodine means the fetus is unable to produce thyroid hormones during this period, which is very dangerous as during this period the brain is developing the ability to hear and perform other motor functions


Cretinism. This results from hypofunction of the thyroid from birth. This may result from iodine deficiency occurring in endemic goiter belts. Babies born to hypothyroid women or those taking antithyroid drugs during pregnancy may develop cretinism At this point, those in medicine are realizing that a deficit of thyroid hormone is the culprit of this adult-onset cretinism, cretinism proper, and goiter. This led to a handful of discoveries and progress being made: 1890: First reports of 'thyroid feeding (crude thyroid tissue by the spoonful

Congenital Hypothyroidism: Symptoms, Causes, and Treatment

  1. A lack of thyroid hormones in the system at an early age can lead to the development of cretinism (intellectual disability) and dwarfism (stunted growth). Most infants now have their thyroid.
  2. History of iodine, cretinism, hypo etc. The last part of the 19th century was a period of great achievements in medicine and endocrinology. The thyroid gland evolved from being considered a rudimentary structure to an organ related to specific diseases. The singular importance of iodine became acknowledged. Graves-Basedow's disease was described
  3. Now let me explain the connection with the levels of TSH, T3 and T4: T3 (triiodthyronine) and T4 (tyroxyne) are two hormones produced by your thyroid gland situated in your neck and TSH (Thyroid Stimulating Hormone) is a hormone produced by the pituitary gland in your brain and TSH - hence the name, stimulates the secretion of T3 and T4

Cretinism, also known as congenital hypothyroidism, is a condition caused by a deficiency of thyroid hormones while a fetus is developing in the womb or shortly after birth. In developing countries, the cause is usually a lack of iodine, but in developed countries, this deficiency is usually caused by a defect in the development of the thyroid. Solitary thyroid nodules. In this case, a single nodule develops in one part of your thyroid gland. Most nodules are noncancerous (benign) and don't lead to cancer. Thyroid cancer. Thyroid cancer is far less common than benign thyroid nodules. A biopsy of a thyroid nodule is very accurate in determining whether it's cancerous. Pregnancy The insufficient production of Thyroxine in mammals can lead to Cretinism, a form of growth retardation where the sufferer severely lacks in both physical and mental development. There are multiple manifestations of Hypothyroidism and roughly three percent of the population is affected by this disorder. It arises for a variety of reasons, and its effects alter according to the organ responsible Cretinism (Congenital Hypothyroidism) Prevalence. Approximately 1 in 4000 newborn infants has a severe deficiency of thyroid function, while even more have mild or partial degrees Studies of populations from North America, Europe, Japan, and Australia, indicate that congenital hypothyroidism affects 1 in 3,000 to 4,000 newborns.. Cretinism is a congenital hypothyroidism, or a underactivity of the thyroid gland at birth. I know a lot of people think different about this disease, I was surprised too when I found out this. That hypothyroidism results in growth retardation, developmental delay and other abnormal features

Video: Difference between Cretinism and Hypothyroidism

Congenital hypothyroidism - Wikipedi

Cretinism - thyroid, gland, treatment, usually, goitre, cretin and sporadic. CRETINISM, the term given to a chronic disease, either sporadic or endemic, arising in early childhood, and due to absence or deficiency of the normal secretion of the thyroid gland. It is characterized by imperfect development both of mind and body At about 12 weeks the fetal thyroid gland begins to function, although some maternal thyroid hormone crosses the placenta to reach the fetal circulation. The most-severe impairment of fetal mental and skeletal development, known as cretinism, occurs when both mother and fetus have thyroid deficiency This second event, influenced by the thyroid gland's morphologic response to its environment (goiter or thyroid atrophy), dictates the final clinical outcome. In conclusion, our hypothesis states that the clinical expression of endemic cretinism is determined by the the sum of two pathophysiologic processes -Congenital cretinism → Thyroid dysgenesis (ectopic or agenesis)-Drugs: lithium or amiodarone. Causes of decreased TSH levels-Primary hyperthyroidism (Grave's)-Secondary hypothyroidism (brain tumor, trauma, infarction of pituitary)-Drugs: steroids-Sick euthyroid syndrome

Congenital hypothyroidism Radiology Reference Article

  1. Cretinism & Hypothyroidism in Children Dr.K.V.Giridhar Associate Prof. of Pediatrics GMC. Ananthapuramu, A.P., India. 9 May 2014 1. 2. • cretinism: 'congenital disease' due to ab sence or deficiency of normal thyroid secre tion, characterized by physicaldeformity, d warfism, and mental retardation, and often by goiter
  2. Cretinism is a syndrome caused by hypothyroidism (underactivity of the thyroid gland) at birth. Two types of cretinism have been distinguished. Endemic cretinism is essentially an iodine deficiency disorder. Insufficient levels of iodine cause maternal hypothyroidism, which increases the incidence of fetal hypothyroidism in the neonate
  3. Sources of iodine include iodized table salt, seafood, seaweed, and vegetables. Decreased iodine intake can cause iodine deficiency and decreased thyroid hormone synthesis. Iodine deficiency can cause cretinism, goiter, myxedema coma, and hypothyroidism. Cellular. Regulation of thyroid hormone starts at the hypothalamus
  4. Cretinism can be caused by thyroid dysgenesis which is the most common cause of cretinism. Thyroid dysgenesis may be due to the absence of the thyroid gland, ectopic growth of the gland, or hypoplastic gland. Thyroid dysgenesis can be also due to mutations in genes as the TSH receptor gene, PAX8 gene, and NK2 homeobox 1. It is thought also that.
  5. Thyroid gland Thyroid is an endocrine gland situated at the root of the neck on either side of the trachea. It has 2 lobes,which are connected in the middle by isthmus. 3. Hormones of thyroid gland- It secretes 3 hormones- 1. Tetraiodothyronine or T4(thyroxine) 2. Tri-iodothyronine or T3 3
  6. CRETINISM TREATMENT: - Thyroid hormone replacement immediately within a few weeks as later no matter how much treatment given then irreversible, permanent mental retardation! GOITRE Large size of the thyroid gland OR thyroid gland enlargement is called Goitre. Causes: 1
  7. istration to mothers on their infant have not been reported. One case of apparent mitigation of cretinism in hypothyroid infants by breastfeeding has been reported, but the amounts of thyroid hormones in milk are not optimal, and this result has been disputed.[9,10] The thyroid hormone content of human milk from the.

11 Celebrities With Thyroid Problems - Verywell Healt

  1. Therefore, the two forms of cretinism might be part of a spectrum of diffuse insult to the developing fetal nervous system, where post-natal thyroid hormone deficiency, in the case of myxedematous cretinism, may result in their characteristic manifestations (65, 66)
  2. cretinism Underactivity of the thyroid gland (hypothyroidism) in children, resulting in poor growth, severe mental retardation and deafness. Commonly the result of a dietary deficiency of iodine; may be congenital if the mother's iodine intake was severely inadequate during pregnancy.Hypothyroidism in adults is myxoedema
  3. Hypothyroidism is thyroid hormone deficiency. It is diagnosed by clinical features such as a typical facial appearance, hoarse slow speech, and dry skin and by low levels of thyroid hormones. In severely iodine-deficient regions worldwide, congenital hypothyroidism (previously termed endemic cretinism) is a major cause of intellectual.
  4. Endemic goiter and cretinism are still observed in some areas, such as regions of Bangladesh, Chad, China, Indonesia, Nepal, Peru, and Zaire. The term sporadic cretinism was initially used to describe the random occurrence of cretinism in nonendemic areas. The cause of these abnormalities was identified as nonfunctioning or absent thyroid glands

Cretinism, as is well known, has been attributed to every cause except the destruction of the thyroid. Chalky water, damp close air, miasma, insufficient food, and so forth, and hereditary influence, have all been credited with the power of causing the imbecile condition which is so familiar to everyone This condition is cretinism. This congenital deficiency of thyroid hormone (congenital hypothyroidism) is usually owing to maternal hypothyroidism. Most of the effects of hypothyroidism are easily reversible. Supplementation of thyroid hormone is a recommended treatment for them if detected in early stages The thyroid gland is an important organ of the endocrine system. It is located at the front of the neck, just above where the collarbones meet. The thyroid makes hormones that control the way every cell in the body uses energy. This process is called metabolism. Hypothyroidism in the newborn may be caused by: A missing or poorly developed. Neonatal hypothyroidism, also called cretinism, condition characterized by the absence, lack, or dysfunction of thyroid hormone production in infancy. This form of hypothyroidism may be present at birth, in which case it is called congenital hypothyroidism, or it may develop shortly after birth, in which case it is known as hypothyroidism acquired in the newborn period

Cretinism: Meaning, Causes, Symptoms, Congenital and

a - decrease in thyroid size and an increase in plasma T4. b- decrease in both thyroid size and plasma T4. c - an increase in both thyriod size and plasma T4. Propyl thiouracil causes all the following are correct : In Cretinism all the following are correct: there is incontinence of urine and foeces Since thyroid-stimulating hormone (188540) and the effects of thyrotropin-releasing hormone (613879) were not tested in the cases of Cross et al. (1968), these and others of the reported cases of 'athyreotic cretinism,' may be instances of 'pituitary cretinism,' i.e., thyrotropin deficiency (275100) Cretinism, also known as congenital hypothyroidism (CH), is a condition where a newborn infant does not have a fully functional thyroid gland.While these terms are now used interchangeably, Cretinism is medically defined to be an untreated case of CH, with or without a goiter Chapter 18—The Endocrine System (Part 2) Terms—Posterior pituitary gland, neurohypophysis, hypothalamohypophyseal tract, oxytocin, antidiuretic hormone (ADH or vasopressin), thyroid gland, isthmus, thyroid follicles, follicular cells, thyroxine (T 4 ), triiodothyronine (T 3 ), parafollicular cells (C cells), calcitonin, thyroxine-binding.

Cretinism Pictures, Causes, Symptoms, Treatment and

Cretinism; Deficiency of thyroid hormone in newborns causes cretinism. N-carboxylbiotinyl lysine Neural tube defects; It is a serious birth defect of the central nervous system due to inadequate minerals and vitamin B12. Cofactor; It is a nonprotein compound needed for enzyme activity. Purine cretinism. (krē`tənĭz'əm), condition produced in infants and children due to lack of thyroid hormone. It usually results from a congenital defect (e.g., absence of the thyroid, presence of only a rudimentary gland, inability of the gland to produce thyroxine). However, it can develop later if there is a lack of iodine in the diet, or if the. Congenital hypothyroidism (CHT) or cretinism refers to a partial or complete loss of function of the thyroid gland that is present at birth (congenital). The thyroid is a small butterfly-shaped. Thyroid autoimmunity and endemic cretinism; Thyroid autoimmunity and endemic cretinism. 111 LABORATORY DATA FOR PATIENTS WITH ENDEMIC CRETINISM Rapid transition from methadone maintenance to naltrexone SIR,-Dr Brewer and Dr Mathew (Sept... Download PDF . 172KB Sizes 2 Downloads 89 Views

Thyroid gland is the first endocrine gland for known deficiency disorder since 1850.Cretinism is the mental and physical growth retardation in patients without thyroid gland. In 1891, these patients were given hormone replacement therapy by administering Crude Thyroid Extract. Hypothyroidism a. Hypothyroidism In Adult Cretinism, or congenital deficiency of thyroid hormone at birth, is a common treatable birth defect. At birth there rarely are any physical findings. This is due to partial placental transfer of maternal thyroid hormone. The physical exam findings are first seen after the first few weeks of infancy, when maternal hormones are lost This is due to an over-stimulated thyroid and inflamed tissues, respectively. Hypothyroidism: Hypothyroidism is a common condition characterized by too little thyroid hormone. In infants, the condition is known as cretinism. Cretinism has very serious side effects, including abnormal bone formation and mental retardation Until about a century ago, 'cretinism' was endemic throughout large parts of the Alps. Sufferers often had a visibly enlarged thyroid gland, and in the worst cases were severely retarded

In severe cases, iodine deficiency can cause a condition called cretinism. When should you call a doctor? Myxedema is a rare but life-threatening complication of hypothyroidism that can be caused. Improvement of cretinism with thyroid extract was also reported around this time. British surgeon William Miller Ord MRCS (1834-1902) coined the term myxedema to describe the nonpitting edema and gelatinous appearance of the skin in hypothyroid patients ( 133 ; 08 ) Neonates (note that cretinism may be present at birth, but usually is apparent within the first few months after birth as a function of the extent of thyroid failure) manifestations: physiologic jaundic Thyroid disease is difficult to diagnose clinically in individuals with Down syndrome because of an overlap of symptoms. This makes thyroid blood screening a particularly important part of the annual preventive medicine screening of each person with Down syndrome. Coleman, M. (1994) Thyroid dysfunction in Down syndrome: A review

1. This is the most common type of thyroid dysfunction. A. Cretinism B. Myxedema coma C. Hyperthyroidism D. Hypothyroidism. 1. Answer: D. Hypothyroidism. Hypothyroidism is a lack of sufficient levels of thyroid hormones to maintain a normal metabolism. This is the most common type of thyroid dysfunction and is common among older women and men Triiodothyronine is preferred over thyroxine in the treatment of: A. Endemic goiter B. Cretinism C. Papillary carcinoma of thyroid D. Myxoedema com

3 Hypothyroidism (Myxedema, Cretinism) Nursing Care Plan

(1991). Thyroid Atrophy in Myxedematous Endemic Cretinism: Possible Role for Growith-Blocking Immunoglobulins. Autoimmunity: Vol. 9, No. 3, pp. 201-206 Cretinism. Since thyroid hormones play an important role in stimulating osteoblastic and osteoclastic activity, their absence results in poor bone development. As a result, these infants are of short stature. Additionally, the development of the central nervous system is also hampered by low thyroid hormone levels Cretinism: Congenital hypothyroidism (underactivity of the thyroid gland at birth), which results in growth retardation, developmental delay, and other abnormal features. Cretinism can be due to deficiency of iodine in the mother's diet during pregnancy Goiter is a condition in which the thyroid gland grows larger. The thyroid gland is a small, butterfly-shaped gland located in the neck, below the Adam's apple. The thyroid gland produces the hormones thyroxine (also called T4) and triiodothyronine (also called T3). (Most of the T4 is changed to T3 outside of the thyroid.

Cretinism (kre'-tin-izm) is caused by a severe hypo- secretion of thyroid hormones in infants. Without treatment, it produces severe mental and physical retardation. Cretinism is characterized by stunted growth, abnormal bone formation, mental retardation, sluggishness, and goiter Cretinism: A. Hyposecretion of the thyroid in infants: Acromegaly : B. Hyposecretion of the thyroid in adults: Cushing's disease : C. Hypersecretion of steroids from the adrenal corte Thyroid hormones, and therefore iodine, are essential for mammalian life. Iodine (as iodide) is widely but unevenly distributed in the earth's environment. Most iodide is found in the oceans (≈50 μg/L), and iodide ions in seawater of endemic cretinism. The diet included available main crops (maize, wheat), vegetables ADVERTISEMENT. Cretinism (noun) A condition of severely stunted physical and mental growth due to the untreated congenital deficiency of thyroid hormones. Myxedema (noun) A form of cutaneous and dermal edema that is secondary to increased deposition of connective tissue components in subcutaneous tissue. from 19th c. Wiktionary

Thyroid and Parathyroid glands - Online Science Notes

cretinism [kre´tĭ-nizm] arrested physical and mental development with dystrophy of bones and soft tissues, due to congenital lack of thyroid gland secretion from hypofunction or absence of the gland. Affected children have a large head, short limbs, puffy eyes, coarse hair, a round abdomen, a thick and protruding tongue with drooling, excessively dry. Cretinism, a condition characterized by mental retardation in children, is caused by deficiency of . Cretinism, a condition characterized by mental retardation in children, is caused by deficiency of . A) growth hormone. B) thyroid hormone. C) insulin. D) aldosterone A dietary deficiency of this element may lead to an enlarged thyroid, or goiter. In young children, a lack of iodine can inhibit hormone production and thereby retard physical, mental, and sexual development —a condition called cretinism. Thyroid Hormones at Work. The thyroid hormones are designated T3, RT3 (Reverse T3), and T4 Background. Iodine is an essential component of thyroid hormones; either low or high intake may lead to thyroid disease. We observed an increase in the prevalence of overt hypothyroidism. 7. Which of these diseases is not related to thyroid glands? (a) Cretinism (b) Myxoedema (c) Goitre (d) Acromegaly. Answer: (d) 8. In chronically deficient patients, this abnormality is directly related to the enlargement of the thyroid gland (a) Impaired conversion of T3 and T4 (b) Reduced activity of thyroperoxidase (c) Elevated levels of TS

Picture of Lingual Thyroid - OTOLARYNGOLOGY HOUSTONThyroid gland123PPT - Hormones Released from the Anterior Pituitary orThyroid Cancer – Symptoms - Risk Factors - Diagnosis粘液水腫性昏睡 - Wikipedia

Cretinism. Cretinism is caused by extreme hypothyroidism during fetal life, infancy, or childhood. This condition is char-acterized especially by failure of body growth and by mental retardation. It results from congenital lack of a thyroid gland (congenital cretinism), from failure of the thyroid gland to produce thyroid hormone because of a. Thyroid (thyroid tablets, USP) Rx only. Content Updated: June 2018. DESCRIPTION . Armour® Thyroid (thyroid tablets, USP)* for oral use is a natural preparation derived from porcine thyroid glands and has a strong, characteristic odor. (T 3 liothyronine is approximately four times as potent as T 4 levothyroxine on a microgram for microgram. What does cretinism mean? A congenital condition caused by a deficiency of thyroid hormone during prenatal development and characterized in childh.. Iodine deficiency is by far the most common preventable cause of mental deficits in the world. The most severe effect of iodine deficiency is endemic cretinism, which is characterized by the combination of mental deficiency, deaf-mutism, and motor rigidity or, less commonly, by severe hypothyroidism

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